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ホーム > 研究業績

原著論文

2025年

　　#: Equal contribution

• Xiaochan Yan, Nami Arakawa, Kanthi Arum Widayati, Laurentia Henrieta Permita Sari Purba, Fahri Fahri, Bambang Suryobroto, Yohey Terai, Hiroo Imai. (2025) Exome analysis reveals species divergence in TYR and identifies species genetic markers in five endemic Macaca species on Sulawesi Island. BMC Ecology and Evolution 25, 66. DOI: 10.1186/s12862-025-02407-6
• Yusuke Hamazaki, Hiroto Akuta, Hikaru Suzuki, Hideyuki Tanabe, Kenji Ichiyanagi, Takuya Imamura, *Masanori Imamura. (2025) Generation and characterization of induced pluripotent stem cells of small apes. Frontiers in Cell and Developmental Biology 13, 1536947. DOI: 10.3389/fcell.2025.1536947
• Junfeng Chen, Kousuke Okimura, Liang Ren, Yusuke Nakane, Tomoya Nakayama, Yang Chen, Kai Fukawa, Soutarou Sugiyama, Takayoshi Natsume, Naoko Suda-Hashimoto, Mayumi Morimoto, Takako Miyabe-Nishiwaki, Takao Oishi, Yuma Katada, Manhui Zhang, Kohei Kobayashi, Shoko Matsumoto, Taiki Yamaguchi, Ying-Jey Guh, Issey Takahashi, Taeko Nishiwaki-Ohkawa, Daiki X. Sato, Yoshiharu Murata, Kenta Sumiyama, Atsushi J. Nagano, Hiroo Imai, *Takashi Yoshimura. (2025) Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases. Nature Communications 16, 3906. DOI: 10.1038/s41467-025-57994-1
• Tao Huang, Arthur Radley, Ayaka Yanagida, Zhili Ren, Francesca Carlisle, Somayyeh Tahajjodi, Dongwan Kim, Paul O’Neill, James Clarke, Madeline A. Lancaster, Zoe Heckhausen, Jingran Zhuo, João Pedro Agostinho de Sousa, Petra Hajkova, Ferdinand von Meyenn, Hiroo Imai, Hiromitsu Nakauchi, Ge Guo, *Austin Smith, *Hideki Masaki. (2025) Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee. Cell Stem Cell 32(4), 627-639. DOI: 10.1016/j.stem.2025.02.002
• *Srishti Tripathi, Hiroo Imai, Ikuma Adachi. (2025) Behavioral (reaction time) and prefrontal cortex response revealed differences in grief vs. sadness perception. Scientific reports 15, 6356. DOI: 10.1038/s41598-025-90387-4
• #Zhijin Liu, #Xiongfei Zhang, #Peipei Wang, #Minheng Hong, Xiaochan Yan, Xiaoqiu Qi, Qian Zhao, Zhenghao Chen, Huajian Nie, Hui Li, Ziwen Li, Liye Zhang, Jiwei Qi, Chaolei He, Nguyen Van Truong, Minh D Le, Tilo Nadler, Hiroo Imai, Christian Roos, Ming Li. (2025) Living on the Rocks: Genomic Analysis of Limestone Langurs Provides Novel Insights into the Adaptive Evolution in Extreme Karst Environments. Genomics, Proteomics & Bioinformatics 10, 23(1):qzaf007. DOI: 10.1093/gpbjnl/qzaf007
• Arisa Ishimura, Ken Iwatsuki and *Hiroo Imai. (2025) Establishment of Intestinal Organoids from Common Marmosets. Organoids 4, 3. DOI: 10.3390/organoids4010003

2024年

　　#: Equal contribution

• Min Hou, Muhammad Shoaib Akhtar, Masahiro Hayashi, Ryuichi Ashino, Akiko Matsumoto-Oda, Takashi Hayakawa, Takafumi Ishida, Amanda D. Melin, Hiroo Imai, *Shoji Kawamura. (2024) Reduction of bitter taste receptor gene family in folivorous colobine primates relative to omnivorous cercopithecine primates. Primates 65, 311–331. DOI: 10.1007/s10329-024-01124-w
• Takuma Sasaki, Kota Katayama, Hiroo Imai, *Hideki Kandori. (2024) Glu102 2.53-mediated early conformational changes in the process of light-induced green cone pigment activation. Biochemistry 63, 843-854. DOI: 10.1021/acs.biochem.3c00594
• *Yukako Katsura, Shuji Shigenobu, Yoko Satta. (2024) Adaptive Evolution and Functional Differentiation of Testis-Expressed Genes in Theria. Animals 14, 2316. DOI: 10.3390/ani14162316
• Shun Hayashi, Takuya Abe, Takeshi Igawa, Yukako Katsura, Yusuke Kazama, *Masafumi Nozawa. (2024) Sex chromosome cycle as a mechanism of stable sex determination. The Journal of Biochemistry 176, 81-95. DOI: 10.1093/jb/mvae045
• Mika Takahi, Yusuke Hamazaki, Kiyoshi Ohnuma, *Masanori Imamura. (2024) Cardiac differentiation of chimpanzee induced pluripotent stem cell lines with different subspecies backgrounds. In Vitro Cellular & Developmental Biology – Animal DOI: 10.1007/s11626-024-00914-2
• Matteo Caldon, Giacomo Mutti, Alessandro Mondanaro, Hiroo Imai, Takayoshi Shotake, Gonzalo Oteo Garcia, Gurja Belay, Jordi Morata, Jean-Rémi Trotta, Francesco Montinaro, Spartaco Gippoliti, *Cristian Capelli. (2024) Gelada genomes highlight events of gene flow, hybridisation and local adaptation that track past climatic changes. Molecular Ecology 33, e17514. DOI:10.1111/mec.17514
• Min Hou, Muhammad Shoaib Akhtar, Masahiro Hayashi, Ashino Ryuichi, Akiko Matsumoto-Oda, Takashi Hayakawa, Takafumi Ishida, Amanda D. Melin, Hiroo Imai, *Shoji Kawamura. (2024) Reduction of bitter taste receptor gene family in folivorous colobine primates relative to omnivorous cercopithecine primates. Primates 65, 311–331. DOI:10.1007/s10329-024-01124-w
• Takuma Sasaki, Kota Katayama, Hiroo Imai, *Hideki Kandori. (2024) Glu1022.53-Mediated Early Conformational Changes in the Process of Light-Induced Green Cone Pigment Activation. Biochemistry 63, 843−854. DOI:10.1021/acs.biochem.3c00594
• *Masanori Imamura, Risako Nakai, Mari Ohnuki, Yusuke Hamazaki, Hideyuki Tanabe, Momoka Sato, Yu Harishima, Musashi Horikawa, Mao Watanabe, Hiroki Oota, Masato Nakagawa, Shunsuke Suzuki, Wolfgang Enard. (2024) Generation of chimpanzee induced pluripotent stem cell lines for cross-species comparisons. In Vitro Cellular & Developmental Biology – Animal 60, 544–554. DOI: 10.1007/s11626-024-00853-y

2023年

　　#: Equal contribution

• Thorell K, Muñoz-Ramírez ZY, Wang D, Sandoval-Motta S, Boscolo Agostini R, Ghirotto S, Torres RC; HpGP Research Network (Yukako Katsura); Falush D, Camargo MC, Rabkin CS. (2023) The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes. Nat Commun 14, 8184. DOI:10.1038/s41467-023-43562-y
• Eun Gyung Park, Yun Ju Lee, Jae-Won Huh, Sang-Je Park, Hiroo Imai, Woo Ryung Kim, Du Hyeong Lee, Jung-Min Kim, Hae Jin Shin, *Heui-Soo Kim. (2023) Identification of microRNAs Derived from Transposable Elements in the Macaca mulatta (Rhesus Monkey) Genome. Genes 14, 1984. DOI:10.3390/genes14111984
• Aksamina Maria Yohanita, *Kanthi Arum Widayati, Tri Atmowidi, Hiroo Imai, Bambang Suryobroto (2023) New localities and sexual dichromatism in Blue-green eyed Spotted Cuscus Spilocuscus wilsoni Helgen et Flannery, 2004 (Mammalia: Marsupialia: Phalangeridae) from Biak Island, Indonesia. Journal of Threatened Taxa 15, 23836-23842. DOI:10.11609/jott.8179.15.9.23836-23842
• K. Shimizu, K. Inoue, T. Oishi, *M. Takada, *Y. Fukada, *H. Imai (2023) Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates. Molecular Brain 16, 31. DOI:10.1186/s13041-023-01022-0
• M. Miwa, Y. Hamazaki, H. Koda, K. Nakamura. Trigger of twin‐fights in captive common marmosets. American Journal of Primatology: e23528 (2023) DOI: 10.1002/ajp.23528

2022年

　　#: Equal contribution

• Mizuno Y, Katayama K, Imai H, Kandori H. (2022) Early Proton Transfer Reaction in a Primate Blue-Sensitive Visual Pigment.Biochemistry 61, 2698-2708. DOI:10.1021/acs.biochem.2c00483
• Nakai R, Hamazaki Y, Ito H, Imamura M. Early neurogenic properties of iPSC-derived neurosphere formation in Japanese macaque monkeys. Differentiation 128: 33-42 (2022) DOI: 10.1016/j.diff.2022.10.002
• Hirata M, Ichiyanagi T, Katoh H, Hashimoto T, Suzuki H, Nitta H, Kawase M, Nakai R, Imamura M, Ichiyanagi K. Sequence divergence and retrotransposon insertion underlie interspecific epigenetic differences in primates. Mol. Biol. and Evol. 39, msac208 (2022) DOI: 10.1093/molbev/msac208
• Itoigawa A#, Hayakawa T#, Zhou Y, Manning AD, Zhang G, Grutzner F, Imai H#. Functional diversity and evolution of bitter taste receptors in egg-laying mammals. Mol. Biol. Evol. in press. DOI:10.1093/molbev/msac107
• Yan Xiaochan, Widayati KA, Itoigawa A, Purba LHPS, Fahri F, Suryobroto B# & Imai H#. Functional divergence of the pigmentation gene melanocortin-1 receptor (MC1R) in six endemic Macaca species on Sulawesi Island. Scientific Reports 12, 7593, DOI:10.1038/s41598-022-11681-z

2021年

　　#: Equal contribution

• Tabata E, Itoigawa A, Koinuma T, Tayama H, Kashimura A, Sakaguchi M, Matoska V, Bauer PO, Oyama F. Non-Insect-Based Diet Leads to Structural and Functional Changes of Acidic Chitinase in Carnivora. Molecular Biology and Evolution 2021 msab331. DOI:10.1093/molbev/msab331
• Toda Y#, Hayakawa T#, Itoigawa A, Kurihara Y, Nakagita T, Hayashi M, Ashino R, Melin AD, Ishimaru Y, Kawamura S, Imai H, Misaka T. (2021) Evolution of the primate glutamate taste sensor from a nucleotide sensor. Current Biology 31, 1–9, DOI:10.1016/j.cub.2021.08.002
• Inaba A, Arinaga A, Tanaka K, Endo T, Hayatsu N, Okazaki Y, Yamane T, Oishi Y, Imai H, Iwatsuki K. (2021) Interleukin-4 Promotes Tuft Cell Differentiation and Acetylcholine Production in Intestinal Organoids of Non-Human Primate. Int. J. Mol. Sci. 22, 7921 DOI:10.3390/ijms22157921
• Itoigawa A, Fierro F, Chaney ME, Lauterbur ME, Hayakawa T, Tosi AJ, Niv MY, Imai H. (2021) Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: An instance of parallel and adaptive functional decline in TAS2R16? Proc. R. Soc. B 288, 20210346. DOI:10.1098/rspb.2021.0346
• Hayashi M, Inaba A, Hakukawa M, Iwatsuki K, Imai H, Masuda K. (2021) Expression of TAS2R14 in the intestinal endocrine cells of non-human primates. Genes & Genomics 43, 259–267 DOI:10.1007/s13258-021-01054-7
• Inaba A, Kumaki S, Arinaga A, Tanaka K, Aihara E, Yamane T, Oishi Y, Imai H, Iwatsuki K. (2021) Generation of intestinal chemosensory cells from nonhuman primate organoids., Biochemical and Biophysical Research Commun. 536, 20-25 DOI:10.1016/j.bbrc.2020.12.044

2020年

　　#: Equal contribution

• Cody A. Ruiz, Morgan E Chaney, Masanori Imamura, Hiroo Imai, Anthony J. Tosi. Predicted structural differences of four fertility-related Y-chromosome proteins in Macaca mulatta, M. fascicularis, and their Indochinese hybrids. Proteins (2020) DOI:10.1002/prot.26021
• Okada S, Kuroki K, Ruiz CA, Tosi AJ, Imamura M. Molecular Histology of spermatogenesis in the Japanese macaque monkey (Macaca fuscata). Primates 2020 DOI:10.1007/s10329-020-00857-8
• Katayama K, Takeyama Y, Enomoto A, Imai H, Kandori H. Disruption of Hydrogen-Bond Network in Rhodopsin Mutations Cause Night Blindness. J. Mol. Biol. 2020 Aug 11:S0022-2836(20)30490-3. DOI:10.1016/j.jmb.2020.08.006.
• Nonaka Y, Hanai S, Katayama K, Imai H, Kandori H. Unique Retinal Binding Pocket of Primate Blue-Sensitive Visual Pigment. Biochemistry. 2020 Jul 21;59(28):2602-2607. DOI:10.1021/acs.biochem.0c00394.
• Shirasu M#, Ito S#, Itoigawa A, Hayakawa T, Kinoshita K, Munechika I, Imai H, Touhara K. Key male glandular odorants attracting female ring-tailed lemurs. Current Biology 30:11 pp2131-2138, 2020. DOI:10.1016/j.cub.2020.03.037
• Kitajima R#, Nakai R#, Imamura T, Kameda T, Kozuka D, Hirai H, Ito H, Imai H, *Imamura M#. Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells. Stem Cell Research 44: 101749 (2020) DOI:10.1016/j.scr.2020.101749
• Lin ZY-C#, Nakai R#, Hirai H, Kozuka D, Katayama S, Nakamura S, Okada S, Kitajima R, Imai H, Okano H, Imamura M#. Reprogramming of chimpanzee fibroblasts into a multipotent cancerous but not fully pluripotent state by transducing iPSC factors in 2i/LIF culture. Differentiation 112: 67-76 (2020) DOI:10.1016/j.diff.2020.01.002
• *Imai H, Hakukawa M, Hayashi M, Iwatsuki K, *Masuda, K. Expression of Bitter Taste Receptors in the Intestinal Cells of Non-Human Primates. Int. J. Mol. Sci. 2020, 21, 902. DOI:10.3390/ijms21030902
• Purba LHPS, Widayati KA, Suzuki-Hashido N, Itoigawa A, Hayakawa T, Nila S, Juliandi B, Suryobroto B, Imai H. Evolution of the bitter taste receptor TAS2R38 in colobines. Primates 2020;10.1007/s10329-020-00799-1, DOI:10.1007/s10329-020-00799-1. ReadOnly Link here

総説

• 沼部令奈, 今井啓雄 (2021) 味覚の個人差と味覚受容体の遺伝子進化. 「アグリバイオ　味覚・食嗜好性研究の最前線」（北隆館）p.23-27
• 今井啓雄，林美沙 (2018) 動物の感覚とヒトとの比較. 「ひと・健康・未来 18 (2018)」
• 今井啓雄 (2017) 味覚受容体の進化と多様性. アグリバイオ 1, 89-91.
• 橋戸（鈴木）南美 (2016) 遺伝子からわかるサルの味覚「なきごえ」52: 3
• 今井啓雄，西栄美子 (2016) 味覚受容体タンパク質の進化と多様性「生物科学」67: 75-84
• 今井啓雄 (2015) サルの味覚を追ってフィールドに。「フィールドプラス」15: 22-23.
• 筒井圭, 今井啓雄 (2015)霊長類苦味受容体の機能的多様性 「比較生理生化学」32: 24-29.
• Imamura M, Hikabe O, Lin ZY, Okano H. (2014) Generation of Germ Cells In Vitro in the Era of Induced Pluripotent Stem Cells. Molecular Reproduction and Development 81: 2-19. PMID:23996404
• 今井啓雄，筒井圭 (2013) 霊長類苦味受容体の多様化「生体の科学」64: 430-431
• 早川卓志，今井啓雄 (2013) チンパンジーにおける苦味感覚の地域差と進化「生物の科学 遺伝」67: 418-424
• 今井啓雄，鈴木南美 (2013) 生息環境に応じた感覚受容体の機能進化「生物物理」53: 194-197. 日本生物物理学会

出版物

2023年

• 今井啓雄. 甘味受容体. 「霊長類学の百科事典」（丸善出版）第4章4-17 分担執筆
• 今村公紀. 霊長類のiPS細胞. 「霊長類学の百科事典」（丸善出版）第4章4-31 分担執筆
• 桂有加子. 性染色体の進化. 「霊長類学の百科事典」（丸善出版）第4章4-12 分担執筆
• 桂有加子. 性決定. 「霊長類学の百科事典」（丸善出版）第4章5-3 分担執筆

2021年

• 今井啓雄, 糸井川壮大. 味覚にかかわる遺伝子 「ヒトゲノム事典」（一色出版）p.263-264 分担執筆
• 糸井川壮大, 今井啓雄. 食にかかわる感覚の種差 「もっとよくわかる！食と栄養のサイエンス～食行動を司る生体恒常性維持システム～」（羊土社）p.35-46 分担執筆

2016年

• 鈴木-橋戸南美, 今井啓雄 霊長類の味覚 「 おいしさの科学的評価・測定法と応用展開」（シーエムシー出版）p.22-33.分担執筆
• 今井啓雄 (2016) 昼間視（明所視）　 「光と生命の事典」（朝倉書店）p.238-239.分担執筆

2013年

• Y. Shichida, T. Yamashita, H. Imai, T. Kishida (2013) Evolution and Senses: Opsins, Bitter Taste, Olfaction.

編集

• Hirai H, Imai H and Go Y (2012) Post-Genome Biology of primates, Primatology Monographs, Springer